Research interests

Our principal area of research regards the ubiquitin ligase Itch. Through different protein-protein interactions, this ligase ubiquitylate several substrates and thus participate to a wide variety of cellular functions in which thoses substrates are involved, including receptor internalization [1], cell signalling [2], apoptosis [3] and cellular differentiation.

We are also involved in projects studying protein expression in the Chrosomus genetic complex from Laurentian lakes [4] as well as visual cortex synaptic plasticity [5].

[1]Angers A, Ramjaun AR, McPherson PS. (2004) The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system. J Biol Chem. 279(12):11471-11479
[2]Azakir BA, Angers A. (2009) Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling. Cell Signal, 21(8), 1326–36
[3]Azakir BA, Desrochers G, Angers A. (2010) The ubiquitin ligase Itch mediates the antiapoptotic activity of EGF by promoting tBid ubiquitylation and degradation. FEBS Journal, 277(5):1319-1330
[4]Angers B, Dallaire A, Vervaet S, Vallières F, Angers A. (2012) The influence of mitochondria in epigenetics revealed through naturally occurring fish cybrids. Current Zoology 58(1): 138-145
[5]Jeyabalaratnam J, Bharmauria V, Bachatene L, Cattan S, Angers A, et al. (2013) Adaptation Shifts Preferred Orientation of Tuning Curve in the Mouse Visual Cortex. PLoS ONE 8(5): e64294.